The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts.

@article{Nelson2014TheSA,
  title={The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts.},
  author={Carol A. Nelson and Michael T Azure and Christopher T Adams and Kurt R. Zinn},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2014},
  volume={55 12},
  pages={2020-5}
}
UNLABELLED P2045 is a peptide analog of somatostatin with picomolar affinity for the somatostatin receptor subtype 2 (SSTR2) upregulated in some pancreatic tumors. Studies were conducted in rat AR42J pancreatic tumor xenograft mice to determine whether (188)Re-P2045 could inhibit the growth of pancreatic cancer in an animal model. METHODS (188)Re-P2045 was intravenously administered every 3 d for 16 d to nude mice with AR42J tumor xenografts that were approximately 20 mm(3) at study… CONTINUE READING