The somatic genomic landscape of chromophobe renal cell carcinoma.

  title={The somatic genomic landscape of chromophobe renal cell carcinoma.},
  author={Caleb F. Davis and Christopher J. Ricketts and Min Wang and Lixing Yang and Andrew D Cherniack and Hui Shen and Christian Buhay and Hyojin Kang and Sang Cheol Kim and Catherine C. Fahey and Kathryn E. Hacker and Gyan Bhanot and Dmitry A Gordenin and Andy Chu and Preethi H. Gunaratne and M Biehl and Sahil Seth and Benny Abraham Kaipparettu and Christopher Aaron Bristow and Lawrence A. Donehower and Eric. M. Wallen and Angela B Smith and Satish K. Tickoo and Pheroze Tamboli and Victor E. Reuter and Laura S. Schmidt and James J Hsieh and Toni K Choueiri and Abraham Ari Hakimi and Lynda Chin and Matthew L Meyerson and Raju Kucherlapati and Woong-Yang Park and A. Gordon Robertson and Peter W. Laird and Elizabeth P Henske and D. J. Kwiatkowski and Peter J. Park and Margaret B. Morgan and Brian Shuch and Donna M. Muzny and David A. Wheeler and W. Marston Linehan and Richard A. Gibbs and W. Kimryn Rathmell and Chad J Creighton},
  journal={Cancer cell},
  volume={26 3},
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting… CONTINUE READING
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