The solvent dependence of enzyme specificity.

  title={The solvent dependence of enzyme specificity.},
  author={Charles R Wescott and Alexander M. Klibanov},
  journal={Biochimica et biophysica acta},
  volume={1206 1},
The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the question of the influence of the reaction medium on enzymatic specificity. Recently, the substrate specificity, enantioselectivity, prochiral selectivity, regioselectivity, and chemoselectivity of enzymes have been found to dramatically depend on the nature of the solvent. This review discusses the scope, possible mechanisms, and implications of this phenomenon, as well as directions of… CONTINUE READING
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