The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.

@article{Casper2014TheSS,
  title={The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.},
  author={Sarah K Casper and Scott J. Schoeller and Danielle M Zgoba and Andrew J. K. Phillips and Thomas J Morien and Gary R. Chaffee and Peter C Sackett and Francis C Peterson and Kirsten Crossgrove and Christopher T. Veldkamp},
  journal={Proteins},
  year={2014},
  volume={82 12},
  pages={3490-6}
}
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and… CONTINUE READING
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