The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding.

Abstract

The solution structure of the hyperstable MYL mutant (R31M/E36Y/R40L) of the Arc repressor of bacteriophage P22 was determined by NMR spectroscopy and compared to that of the wild-type Arc repressor. A backbone rmsd versus the average of 0.37 A was obtained for the well-defined core region. For both Arc-MYL and the wild-type Arc repressor, evidence for a… (More)

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@article{Nooren1999TheSS, title={The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding.}, author={Irene M.A. Nooren and Alex Rietveld and Giuseppe Melacini and Robert T. Sauer and R. Kaptein and Rolf Boelens}, journal={Biochemistry}, year={1999}, volume={38 19}, pages={6035-42} }