The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms.

@article{Blaschitz2005TheSP,
  title={The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms.},
  author={Astrid Blaschitz and Herbert Juch and A. Volz and Heinz Hutter and Christine Daxb{\"o}ck and Gernot Desoye and Gottfried Dohr},
  journal={Molecular human reproduction},
  year={2005},
  volume={11 10},
  pages={699-710}
}
In the context of implantation and pregnancy, several immunomodulating functions have been attributed to the different HLA-G isoforms. Increasing attention is now being addressed to the actively secreted soluble forms, because they might have a systemic function or could be useful as diagnostic tools. However, the cellular source of secretion, even during pregnancy, where HLA-G expression level is known to be highest, is still under debate. To elucidate the conflicting results, we investigated… CONTINUE READING
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Biology and functions of human leukocyte anti - genG in health and sickness

  • J LeMaoult, M LeDiscorde, +4 authors ED Carosella
  • Tissue Antigens
  • 2003
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