The solubility of anesthetic gases in lipid bilayers.

@article{Smith1981TheSO,
  title={The solubility of anesthetic gases in lipid bilayers.},
  author={Robert Andrew Leighton Smith and Elsie Porter and Keith W Miller},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={645 2},
  pages={
          327-38
        }
}
We have measured the lipid/gas partition coefficients at various temperatures of eight anesthetic agents in two sonicated lipid bilayers containing either 96% egg phosphatidylcholine/4% phosphatidic acid or 64% egg phosphatidylcholine/3% phosphatidic acid/33% cholesterol. The Bunsen lipid/gas partition coefficients in the pure phospholipid bilayer at 25 degrees C were: methoxyflurane 820 (interpolated), halothane 150, isoflurane 140, fluroxene 52, xenon 1.4, sulfur hexafluoride 0.24, carbon… CONTINUE READING
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