The solid-phase Nicholas reaction: scope and limitations.

  title={The solid-phase Nicholas reaction: scope and limitations.},
  author={Natalie I Gachkova and Johan A Cassel and Stefanie Leue and Nina C Kann},
  journal={Journal of combinatorial chemistry},
  volume={7 3},
Two libraries of alpha-substituted alkynes has been prepared on solid phase using a sequential Sonogashira/Nicholas reaction approach. The scope of nucleophiles in the Nicholas reaction on solid phase has been investigated, including carbon, oxygen, nitrogen, sulfur, fluoride, and hydride nucleophiles. The conditions for the reaction sequence have been… CONTINUE READING