The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics.

@article{Kogai2012TheSI,
  title={The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics.},
  author={T. Kogai and G. Brent},
  journal={Pharmacology & therapeutics},
  year={2012},
  volume={135 3},
  pages={
          355-70
        }
}
Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β-emitting radioactive iodide is routinely utilized to target remnant thyroid cancer and metastasis after total thyroidectomy. Stimulation of NIS expression by high levels of thyroid-stimulating hormone is necessary to achieve radioiodide uptake into thyroid cancer that is sufficient for therapy. The majority of breast… Expand
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