The sodium channel activator Brevetoxin-3 uncovers a multiplicity of different open states of the cardiac sodium channel.

@article{Schreibmayer1992TheSC,
  title={The sodium channel activator Brevetoxin-3 uncovers a multiplicity of different open states of the cardiac sodium channel.},
  author={Wolfgang Schreibmayer and G Jeglitsch},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1104 2},
  pages={233-42}
}
The interaction of Brevetoxin 3 (Pbtx-3), a sodium channel activator, with the cardiac sodium channel was studied at the single channel level. It was found that Pbtx-3 (20 microM) shifted steady-state activation to negative potentials, without major effects on the time course of macroscopic activation or macroscopic currents decay, as calculated from… CONTINUE READING