The sodium bile salt cotransport family SLC10

  title={The sodium bile salt cotransport family SLC10},
  author={Bruno Hagenbuch and Paul A. Dawson},
  journal={Pfl{\"u}gers Archiv},
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly… CONTINUE READING
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