The sodium/glucose cotransport family SLC5

@article{Wright2004TheSC,
  title={The sodium/glucose cotransport family SLC5},
  author={Ernest M. Wright and Eric Turk},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={447},
  pages={510-518}
}
The sodium/glucose cotransporter family (SLCA5) has 220 or more members in animal and bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the central nervous system. The functions of nine have been revealed by studies using heterologous expression systems: six are tightly coupled plasma membrane Na+/substrate cotransporters for solutes such as glucose, myo-inositol and iodide; one is a Na+/Cl−/choline cotransporter; one is an anion transporter; and another… Expand

Figures from this paper

Glucose transport families SLC5 and SLC50.
  • E. Wright
  • Biology, Medicine
  • Molecular aspects of medicine
  • 2013
TLDR
The atomic structure of a closely related bacterial homolog has been solved and the structural core is common to six unrelated transporters, e.g. members of the SLC6 family of neurotransporter, and the conclusion that these work by a similar mechanism. Expand
INHIBITORS OF SODIUM/GLUCOSE COTRANSPORT
TLDR
The biology of theMembers of the sodium/glucose cotransport family are described, giving special attention to those which are members of the human genome, and the importance and pharmacological profile of SGLT inhibitors, especially inhibitors of S GLT2 are outlined. Expand
Biology of human sodium glucose transporters.
TLDR
A personal review of advances in the genetics, molecular biology, biochemistry, biophysics, and structure of SGLTs, including cotransporters for sugars, anions, vitamins, and short-chain fatty acids. Expand
Functional properties and genomics of glucose transporters.
TLDR
This review reports both the genomic structure and function of each transporter as well as intra-species comparative genomic analysis of some of these transporters and introduces some pathophysiological roles of thesetransporters in human. Expand
SLC5 and SLC2 transporters in epithelia-cellular role and molecular mechanisms.
TLDR
Based on the sequence data and biochemical and biophysical analyses, the role of extramembranous loops in sugar and inhibitor binding can be delineated and Crystal structures and homology modeling of SGLT reveal that the sugar translocation involves operation of two hydrophobic gates and intermediate exofacial and endofacial occluded states of the carrier in an alternating access model. Expand
Glucose transporters in cattle - a review.
TLDR
In this review, genomic structure and function of the bovine glucose transporters are described and intra-species comparative analyses o the amino acid identities of glucose transporter proteins is also described, as well as the information on the nucleotide sequence polymorphisms in the b beef glucose transporter genes. Expand
Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate*
TLDR
It is concluded that slc5a8 is expressed abundantly in the kidney and that it plays a role in the active reabsorption of lactate. Expand
Putative role of the H+/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney
TLDR
It is shown that SLC45A3 is a novel sugar transporter in kidney and hypothesise that the disaccharide sucrose, and probably the monosaccharides glucose and fructose, may serve as compatible osmolytes in urine. Expand
Bridging the gap between structure and kinetics of human SGLT1.
TLDR
The results establish that glucose and phlorizin occupy the same binding site and that F101 is involved in binding to the phloretin group of the inhibitor, and provide a bridge between kinetics and structural studies of cotransporters. Expand
The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins.
TLDR
The relationships between ion interactions and oligomerization of SLC6 transporters are established, and the reactivity with methanethiosulfonate reagents of cysteines placed in strategic positions in the transporter provides a readout for conformational changes upon ion or substrate binding. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 94 REFERENCES
Structure and function of the Na+/glucose cotransporter.
TLDR
It is proposed that the N-terminal domains of SGLT1 are responsible for Na+ binding and/or translocation, and that Na+/glucose cotransport results from interactions between the N and C-terminAL domains of the protein. Expand
The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21.
TLDR
The inability of a trisomic 21 cell to downregulate expression of three copies of this osmoregulatory gene could result in increased flux of both myo-inositol and Na+ across the plasma membrane, and potential consequences include perturbations in the cell membrane potential and tissue osmolyte levels. Expand
Regulation of Na+/glucose cotransporters.
TLDR
It is concluded that PKA and PKC regulate rabbit SGLT1 activity by modulating the number of cotransporters in the plasma membrane and that this occurs through regulation of exocytosis and endocytotic. Expand
Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.
  • M. Hediger, E. Turk, E. Wright
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1989
TLDR
The cloning and sequencing of the human intestinal Na+/glucose cotransporter (SGLT1) is reported and its structure is compared with other cloned transporters and it is inferred that the mammalian Na+./glUCose and prokaryote Na+ /proline cOTransporters share a common ancestral gene. Expand
Structure of the human Na+/glucose cotransporter gene SGLT1.
TLDR
The entire human SGLT1 Na+/glucose cotransporter gene from cosmid and lambda phage clones representing a genomic region of 112 kilobases is mapped and a new missense mutation in exon 1 causing glucose/galactose malabsorption is described, the first Na(+)-dependent cotranporter gene structure reported. Expand
Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter.
TLDR
Low-stringency screening with the human intestinal Na(+)-glucose cotransporter S GLT1 is used to isolate a 2,271-nucleotide cDNA (Hu14) from human kidney, which is 59% identical at the amino acid level to SGLT1 and has a similar number and arrangement of predicted membrane-spanning regions. Expand
Expression cloning and cDNA sequencing of the Na+/glucose co-transporter
TLDR
The cloned DNA suggests that the mammalian Na+-driven transporter has no evolutionary relationship to the other sugar transporters, and no homology between the Na+/glucose co-transporter and either the mammalian facilitated glucose carrier or the bacterial sugar transport proteins. Expand
Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter
GLUCOSE/galactose malabsorption (GGM) is an autosomal recessive disease manifesting within the first weeks of life and characterized by a selective failure to absorb dietary glucose and galactoseExpand
Identification of a Novel Na+/myo-Inositol Cotransporter*
TLDR
The expressed protein, which was expressed in Xenopus laevis oocytes that were subsequently voltage-clamped and exposed to likely substrates and displays a current-voltage relationship similar to that seen with SMIT, is named SMIT2 and exhibits phlorizin-inhibitable presteady-state currents and substrate-independent “Na+ leak” currents similar to those of related cotransporters. Expand
Cotransport of water by the Na+/glucose cotransporter.
TLDR
It is demonstrated that 260 water molecules are directly coupled to each sugar molecule transported and estimate that in the human intestine this accounts for 5 liters of water absorption per day, suggesting that cotransporters play an important role in water homeostasis. Expand
...
1
2
3
4
5
...