The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5α-dihydroprogesterone in psychiatric disorders

@article{Guidotti2001TheSM,
  title={The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5$\alpha$-dihydroprogesterone in psychiatric disorders},
  author={Alessandro Guidotti and Erbo Dong and K. Matsumoto and Graziano Pinna and Ann M. Rasmusson and Erminio Costa},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={110-115}
}
Allopregnanolone (3alpha,5alpha-TH PROG) and 5alpha-dihydroprogesterone (5alpha-DH PROG), the two most important neuroactive steroids synthesized in the brain, potently modulate neuronal activity by allosterically regulating GABA action at GABA(A) receptors or by changing specific GABA(A) receptor subunit gene expression, respectively. We recently reported [Proc. Natl. Acad. Sci. USA 95 (1998) 3239] that in patients with severe depression there is a decrease in the CSF levels of 3alpha,5alpha… Expand
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