The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima

@article{ORourke2004TheSM,
  title={The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima},
  author={M. O’Rourke and T. Chen and D. Hirst and P. Rao and C. Shaw},
  journal={Regulatory Peptides},
  year={2004},
  volume={121},
  pages={65-72}
}
Structural homologues of vertebrate regulatory peptides found in defensive skin secretions of anuran amphibians often display enhanced bioactivity and receptor binding when compared with endogenous mammalian peptide ligands. Maximakinin, a novel N-terminally extended bradykinin (DLPKINRKGPRPPGFSPFR) from the skin venom of a Chinese toad (Bombina maxima), displays such activity enhancement when compared with bradykinin but is additionally highly selective for mammalian arterial smooth muscle… Expand
Toxic activity and protein identification from the parotoid gland secretion of the common toad Bufo bufo.
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