The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.

@article{Talib2014TheSO,
  title={The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.},
  author={Javid Husain Talib and Jair Chau Kwan and Aldwin Suryo Rahmanto and Paul K Witting and Morton James Pryce Davies},
  journal={The Biochemical journal},
  year={2014},
  volume={457 1},
  pages={
          89-97
        }
}
Smokers have an elevated risk of cardiovascular disease but the origin(s) of this increased risk are incompletely defined. Considerable evidence supports an accumulation of the oxidant-generating enzyme MPO (myeloperoxidase) in the inflamed artery wall, and smokers have high levels of SCN(-), a preferred MPO substrate, with this resulting in HOSCN (hypothiocyanous acid) formation. We hypothesized that this thiol-specific oxidant may target the Zn(2+)-thiol cluster of eNOS (endothelial nitric… CONTINUE READING
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