The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.

  title={The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.},
  author={Jihan Talib and J. Kwan and Aldwin Suryo Rahmanto and P. Witting and M. Davies},
  journal={The Biochemical journal},
  volume={457 1},
  • Jihan Talib, J. Kwan, +2 authors M. Davies
  • Published 2014
  • Chemistry, Medicine
  • The Biochemical journal
  • Smokers have an elevated risk of cardiovascular disease but the origin(s) of this increased risk are incompletely defined. Considerable evidence supports an accumulation of the oxidant-generating enzyme MPO (myeloperoxidase) in the inflamed artery wall, and smokers have high levels of SCN(-), a preferred MPO substrate, with this resulting in HOSCN (hypothiocyanous acid) formation. We hypothesized that this thiol-specific oxidant may target the Zn(2+)-thiol cluster of eNOS (endothelial nitric… CONTINUE READING
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