The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins.

@article{Hohl1995TheSP,
  title={The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins.},
  author={D. Hohl and Pierre A. de Viragh and F Amiguet-Barras and Susan Gibbs and Claude M P Backendorf and Marcel Huber},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={104 6},
  pages={902-9}
}
Loricrin, involucrin, small proline-rich protein (SPRR)1, SPRR2, and SPRR3 genes are located within a cluster of 1.5 Mbp on chromosome 1q21 and most likely evolved from a common ancestor. Monospecific polyclonal antibodies and cDNA probes were produced to investigate SPRR transcripts and proteins. SPRR expression was restricted to terminally differentiating squamous cells, preferentially located at the cell periphery, and immunoreactivity was greatly reduced in cells with a mature cornified… CONTINUE READING

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