The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.

@article{Pu2012TheSP,
  title={The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.},
  author={Jeffrey Jiayu Pu and Rong Hu and Galina L. Mukhina and Hetty E. Carraway and Michael A. McDevitt and Robert A Brodsky},
  journal={Haematologica},
  year={2012},
  volume={97 8},
  pages={1225-33}
}
BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation. Many patients with aplastic anemia and myelodysplastic syndromes also harbor small populations of glycosylphosphatidylinositol-anchor deficient cells. Patients with aplastic anemia often evolve into paroxysmal nocturnal hemoglobinuria; however, myelodysplastic syndromes seldom evolve into… CONTINUE READING

References

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Neutral evolution in paroxysmal nocturnal hemoglobinuria.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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