The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo.

@article{Jiang2016TheSI,
  title={The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo.},
  author={Yongsheng Jiang and Qinghua Meng and Bo Chen and Haiyu Shen and Bing Yan and Baoyou Sun},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={478 1},
  pages={
          293-299
        }
}
In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, same AT406 treatment was non-cytotoxic to pancreatic epithelial HPDE6c7 cells. AT406 increased caspase-3/-9 activity and provoked apoptosis in the pancreatic cancer cells. Reversely… CONTINUE READING

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