The small intestine as a model for evaluating adult tissue stem cell drug targets.

@article{Potten2003TheSI,
  title={The small intestine as a model for evaluating adult tissue stem cell drug targets.},
  author={Christopher S. Potten and Catherine Booth and Danielle Hargreaves},
  journal={Cell proliferation},
  year={2003},
  volume={36 3},
  pages={115-29}
}
Adult tissue stem cells are defined and some current controversies are discussed. These crucial cells are responsible for all cell production in renewing tissues, and play a vital role in tissue regeneration. Although reliable stem cell markers are generally unavailable for adult epithelial tissues, the small intestinal crypts are an excellent in vivo model system to study stem cells. Within this tissue, the stem cells have a very well-defined cell position, allowing accurate definition of stem… CONTINUE READING

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