The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

Abstract

SHP (small heterodimer partner, NR1I0) is an atypical orphan member of the nuclear receptor subfamily in that it lacks a DNA-binding domain. It is mostly expressed in the liver, where it binds to and inhibits the function of nuclear receptors. SHP is up-regulated by primary bile acids, through the activation of their receptor farnesoid X receptor, leading… (More)

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@article{Ourlin2003TheSH, title={The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.}, author={Jean Claude Ourlin and Fr{\'e}d{\'e}ric Lasserre and Thierry Pineau and Jean Michel Fabre and Antonio Sa-Cunha and Patrick Maurel and M. C. Vilarem and Jean Marc Pascussi}, journal={Molecular endocrinology}, year={2003}, volume={17 9}, pages={1693-703} }