The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

@article{Yerbury2012TheSH,
  title={The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro},
  author={Justin J Yerbury and Dane Gower and Laura Z. Vanags and Kate Roberts and Jodi A. Lee and Heath Ecroyd},
  journal={Cell Stress and Chaperones},
  year={2012},
  volume={18},
  pages={251-257}
}
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease. The mechanism that underlies amyotrophic lateral sclerosis (ALS) pathology remains unclear, but protein inclusions are associated with all forms of the disease. Apart from pathogenic proteins, such as TDP-43 and SOD1, other proteins are associated with ALS inclusions including small heat shock proteins. However, whether small heat shock proteins have a direct effect on SOD1 aggregation remains unknown. In this study, we… CONTINUE READING

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