The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines.

@article{Oesterreich1993TheSH,
  title={The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines.},
  author={Steffi Oesterreich and C n Weng and Ming Qiu and Susan G. Hilsenbeck and Charles Osborne and Suzanne A W Fuqua},
  journal={Cancer research},
  year={1993},
  volume={53 19},
  pages={4443-8}
}
An emerging body of evidence suggests that the heat shock proteins (hsp) may be involved in drug resistance. When hsp are induced by elevated temperatures, resistance to doxorubicin (Dox), but not to other commonly used chemotherapeutic agents, is induced in breast cancer cells. To evaluate the role of hsp27 in this phenomenon, we have transfected MDA-MB-231 breast cancer cells, which normally express low levels of hsp27, with a full-length hsp27 construct. These hsp27-overexpressing cells now… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
80 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 80 extracted citations

Similar Papers

Loading similar papers…