The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway

@article{Oshita2010TheSH,
  title={The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway},
  author={Shayna E. Oshita and Feng Chen and Toni Kwan and Fruma Yehiely and Vincent L Cryns},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={124},
  pages={307-315}
}
Members of the conserved small heat shock protein (sHSP) family, such as αB-crystallin and Hsp27, are constitutively expressed in diverse malignancies and have been linked to several hallmark features of cancer including apoptosis resistance. In contrast, the sHSP HspB2/MKBP, which shares an intergenic promoter with αB-crystallin, was discovered as a chaperone of the myotonic dystrophy protein kinase and has not been previously implicated in apoptosis regulation. Here we describe a new function… CONTINUE READING

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References

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Expression profile of the small heat-shock protein alpha-B-crystallin in operated-on non-small-cell lung cancer patients: clinical implication.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery • 2010

Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2008

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

Proceedings of the National Academy of Sciences of the United States of America • 2008
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