The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted.

@article{Melegari1997TheSE,
  title={The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted.},
  author={Margherita Melegari and Pier Paolo Scaglioni and Jack R Wands},
  journal={Journal of virology},
  year={1997},
  volume={71 7},
  pages={5449-54}
}
Naturally occurring deletions in the hepatitis B virus pre-S1 domain have been frequently found during persistent viral infection. In this study we have investigated the functional properties of a mutant viral genome that carries an in-frame deletion of 183 nucleotides in the pre-S1 region. This deletion removes the promoter of the small envelope gene. Transfection into human hepatocellular carcinoma cells of a replication-competent construct containing this deletion resulted in an increase of… CONTINUE READING

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