The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100).

@article{Shimojo2013TheSC,
  title={The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100).},
  author={Masahito Shimojo and Yoshie Shudo and Masatoshi Ikeda and Tomoyo Kobashi and Seiji Ito},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 10},
  pages={1258-68}
}
UNLABELLED Small cell lung cancer (SCLC) is a highly malignant form of cancer, which originates from primitive neuroendocrine cells in the lung. SCLC cells express several autocrine neurotransmitters/neuropeptides and their respective receptors. Expression of these neuronal markers is frequently regulated by RE1-silencing transcription factor (REST). In SCLC cells, an SCLC-specific isoform of REST (sREST) is highly expressed, whereas REST expression is undetectable, suggesting that the… CONTINUE READING

Similar Papers

Loading similar papers…