The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin αIIbβ3-mediated adhesion and spreading

@inproceedings{Haataja2002TheSG,
  title={The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin αIIbβ3-mediated adhesion and spreading},
  author={Leena Haataja and Vesa Kaartinen and John Groffen and Nora Heisterkamp},
  year={2002}
}
Abstract There are only three human isoforms of the small GTPase Rac, which together regulate a variety of cellular processes, including those related to actin cytoskeletal reorganization. A role for Rac3 in integrin-mediated adhesion and spreading has not been defined. We here report that CIB, a protein that binds to the αIIbβ3 fibrinogen receptor, interacts exclusively with activated (V12) Rac3 but not Rac1 or Rac2. Binding of V12Rac3 to CIB was mediated by the C-terminal end of Rac3 and by… CONTINUE READING

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