The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.

@article{Leblanc2011TheSG,
  title={The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.},
  author={Julie Leblanc and Xuan Zhang and Dorothy McKee and Zhiguo Wang and Ruixin Li and Chunqi Ma and Q-Y Sun and X. John{\'e} Liu},
  journal={Molecular human reproduction},
  year={2011},
  volume={17 5},
  pages={305-16}
}
Polar body emission is a specialized cell division throughout the animal kingdom, serving to reduce chromosome ploidy while preserving the egg cytoplasm. Critical to polar body emission are the asymmetric positioning of the meiotic spindle prior to anaphase, with one pole attached to the oocyte cortex, and the simultaneous membrane protrusion during subsequent cytokinesis. We have shown that, during Xenopus oocyte maturation, the small GTPase Cdc42 promotes membrane protrusion while a classical… CONTINUE READING

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