The slow inhibitory postsynaptic potential in rat hippocampal CA1 neurones is blocked by intracellular injection of QX-314.

@article{Nathan1990TheSI,
  title={The slow inhibitory postsynaptic potential in rat hippocampal CA1 neurones is blocked by intracellular injection of QX-314.},
  author={T P Nathan and Morten Skovgaard Jensen and John D.C. Lambert},
  journal={Neuroscience letters},
  year={1990},
  volume={110 3},
  pages={309-13}
}
Intracellular recordings were made from CA1 pyramidal neurones in the rat hippocampus slice preparation. The recording electrodes contained potassium acetate (4 M) with or without the quaternary lidocaine derivative, QX-314 (50 mM). Both fast (f) and slow (s) inhibitory postsynaptic potentials (IPSP) were evoked by low-frequency orthodromic stimulation. The s-IPSP was rapidly reduced by QX-314 injection. It decreased along a similar time course to the dV/dt of the action potential (AP). The f… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Connections & Topics

Mentioned Connections BETA
It is concluded that conductance through the K+ channels which are coupled to GABAB receptors is readily blocked by QX-314 , while the Cl- channels which are coupled to GABAA receptors and the cation channels coupled to the glutamate receptors are relatively resistant to the local anaesthetic .
It is concluded that conductance through the K+ channels which are coupled to GABAB receptors is readily blocked by QX-314 , while the Cl- channels which are coupled to GABAA receptors and the cation channels coupled to the glutamate receptors are relatively resistant to the local anaesthetic .
LidocaineMapped fromQX-314
The recording electrodes contained potassium acetate ( 4 M ) with or without the quaternary lidocaine derivative , QX-314 ( 50 mM ) .
All Topics