The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects

@article{Volkow2005TheSA,
  title={The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects},
  author={N. Volkow and Gene-Jack Wang and J. Fowler and S. Learned-Coughlin and Julia Yang and J. Logan and D. Schlyer and J. Gatley and Christopher T. Wong and Wei Zhu and N. Pappas and M. Schueller and M. Jayne and P. Carter and D. Warner and Yu-Shin Ding and C. Shea and Youwen Xu},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={640-646}
}
BACKGROUND (2S,3S)-2-(3-Chlorophenyl)-3,5,5,-trimethyl-2-morpholinol hydrochloride (radafaxine) is a new antidepressant that blocks dopamine transporters (DAT). A concern with drugs that block (DAT) is their potential reinforcing effects and abuse liability. Using positron emission tomography (PET) we have shown that for DAT-blocking drugs to produce reinforcing effects they must induce >50% DAT blockade and the blockade has to be fast (within 15 minutes). This study measures the potency and… Expand
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TLDR
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TLDR
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