The slow:fast substitution ratio reveals changing patterns of natural selection in γ-proteobacterial genomes

@article{Shapiro2009TheSS,
  title={The slow:fast substitution ratio reveals changing patterns of natural selection in γ-proteobacterial genomes},
  author={B. Jesse Shapiro and Eric Alm},
  journal={The ISME Journal},
  year={2009},
  volume={3},
  pages={1180-1192}
}
Different microbial species are thought to occupy distinct ecological niches, subjecting each species to unique selective constraints, which may leave a recognizable signal in their genomes. Thus, it may be possible to extract insight into the genetic basis of ecological differences among lineages by identifying unusual patterns of substitutions in orthologous gene or protein sequences. We used the ratio of substitutions in slow- versus fast-evolving sites (nucleotides in DNA, or amino acids in… CONTINUE READING