The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.

@article{Fujisawa2007TheSR,
  title={The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.},
  author={Kazuko Fujisawa and Jeffrey L. Wrana and Joseph G Culotti},
  journal={Science},
  year={2007},
  volume={317 5846},
  pages={1934-8}
}
The SAX-3/roundabout (Robo) receptor has SLT-1/Slit-dependent and -independent functions in guiding cell and axon migrations. We identified enhancer of ventral-axon guidance defects of unc-40 mutants (EVA-1) as a Caenorhabditis elegans transmembrane receptor for SLT-1. EVA-1 has two predicted galactose-binding ectodomains, acts cell-autonomously for SLT-1/Slit-dependent axon migration functions of SAX-3/Robo, binds to SLT-1 and SAX-3, colocalizes with SAX-3 on cells, and provides cell… CONTINUE READING
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