The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.

@article{Kligys2007TheSF,
  title={The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.},
  author={Kristina R Kligys and Jessica N Claiborne and Phillip J Debiase and Susan B Hopkinson and Yvonne Wu and Kensaku Mizuno and Jonathan C R Jones},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 44},
  pages={32520-8}
}
The motility of keratinocytes is an essential component of wound closure and the development of epidermal tumors. In vitro, the specific motile behavior of keratinocytes is dictated by the assembly of laminin-332 tracks, a process that is dependent upon alpha6beta4 integrin signaling to Rac1 and the actin-severing protein cofilin. Here we have analyzed how cofilin phosphorylation is regulated by phosphatases (slingshot (SSH) or chronophin (CIN)) downstream of signaling by alpha6beta4 integrin… CONTINUE READING

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2016
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