The sleeping beauty transposon vector system for treatment of rare genetic diseases: an unrealized hope?

@article{Boehme2015TheSB,
  title={The sleeping beauty transposon vector system for treatment of rare genetic diseases: an unrealized hope?},
  author={Philip Boehme and Johannes Doerner and Manish Solanki and Liu Jing and Wenli Zhang and Anja Ehrhardt},
  journal={Current gene therapy},
  year={2015},
  volume={15 3},
  pages={
          255-65
        }
}
Rare genetic diseases account for a considerable amount of fatalities and even their 'mild' or 'non-lethal' forms can produce drastic and undesirable discomfort to affected individuals. Various gene therapeutic approaches were tested for developing novel therapeutic concepts to treat these genetic diseases. Sleeping Beauty (SB) transposase represents one of these gene therapeutic systems which can be utilized for stable phenotypic correction. It is a transposable element which was resurrected… CONTINUE READING
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