The sleep switch: hypothalamic control of sleep and wakefulness

@article{Saper2001TheSS,
  title={The sleep switch: hypothalamic control of sleep and wakefulness},
  author={Clifford B. Saper and Thomas C. Chou and Thomas E. Scammell},
  journal={Trends in Neurosciences},
  year={2001},
  volume={24},
  pages={726-731}
}
More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions. The ventrolateral preoptic nucleus contains GABAergic and galaninergic neurons that are active during sleep and are necessary for normal sleep. The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed… Expand
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