The sleep switch: hypothalamic control of sleep and wakefulness

@article{Saper2001TheSS,
  title={The sleep switch: hypothalamic control of sleep and wakefulness},
  author={Clifford B. Saper and Thomas C. Chou and Thomas E. Scammell},
  journal={Trends in Neurosciences},
  year={2001},
  volume={24},
  pages={726-731}
}

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References

SHOWING 1-10 OF 67 REFERENCES

Activation of Ventrolateral Preoptic Neurons During Sleep

The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral preoptic neurons innervate the tuberomammillary nucleus, a posterior hypothalamic cell group thought to participate in the modulation of arousal.

[Specific neurons for wakefulness in the posterior hypothalamus in the cat].

Using a single unit recording technique in freely moving Cats, we have demonstrated the presence of two groups of neurons in the ventrolateral part of the caudal hypothalamus. One is characterized by

Effects of lateral preoptic area application of orexin‐A on sleep–wakefulness

The results suggest that the IPOA orexin terminal field or adjacent structures may be a locus of arousal regulation by this peptide and a substrate of sleep-wake regulatory deficits in narcolepsy.

Identification of sleep-promoting neurons in vitro

It is proposed that the reciprocal inhibitory interaction of such VLPO neurons with the noradrenergic, serotoninergic and cholinergic waking systems to which they project is a key factor for promoting sleep.

Fos Expression in Orexin Neurons Varies with Behavioral State

Results suggest that activation of orexin neurons may contribute to the promotion or maintenance of wakefulness, and relative inactivity of oxin neuron may allow the expression of sleep.

Dopaminergic Role in Stimulant-Induced Wakefulness

D dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil.
...