The sleep switch: hypothalamic control of sleep and wakefulness

@article{Saper2001TheSS,
  title={The sleep switch: hypothalamic control of sleep and wakefulness},
  author={C. Saper and T. Chou and T. Scammell},
  journal={Trends in Neurosciences},
  year={2001},
  volume={24},
  pages={726-731}
}
More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions. The ventrolateral preoptic nucleus contains GABAergic and galaninergic neurons that are active during sleep and are necessary for normal sleep. The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed… Expand
1,396 Citations
The role of the hypothalamus in cortical arousal and sleep homeostasis
  • 1
  • PDF
The Neurobiology of Sleep and Wakefulness.
  • 94
Neurochemistry of Sleep
  • 2
Hypothalamic regulation of sleep and circadian rhythms
  • 2,044
  • PDF
[Sleep-wake cycle mechanisms].
  • 21
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
  • 120
Identification of sleep-promoting neurons in vitro
  • 425
  • PDF
Fos Expression in Orexin Neurons Varies with Behavioral State
  • 612
  • PDF
Dopaminergic Role in Stimulant-Induced Wakefulness
  • 655
  • PDF
...
1
2
3
4
5
...