The sleep switch: hypothalamic control of sleep and wakefulness
@article{Saper2001TheSS, title={The sleep switch: hypothalamic control of sleep and wakefulness}, author={Clifford B. Saper and Thomas C. Chou and Thomas E. Scammell}, journal={Trends in Neurosciences}, year={2001}, volume={24}, pages={726-731} }
1,490 Citations
The role of the hypothalamus in cortical arousal and sleep homeostasis
- Psychology, BiologybioRxiv
- 2020
It is shown that stimulation of inhibitory neurons in the preoptic hypothalamus does not merely trigger awakening from sleep, but the resulting awake state is also characterized by increased cortical activity, which is proposed as a key intrinsic variable in shaping the architecture of sleep/wake states across the 24h day.
Orexin and Hypothalamic Control of Sleep and Waking
- Biology, Psychology
- 2006
This chapter reviews the hypothalamic systems regulating sleep/wake behavior and highlights how the orexin neurons play an essential role in stabilizing wakefulness and integrating arousal with other hypothalamic functions.
Neuroanatomy of Sleep-Wake Regulation and its Application to Pharmacotherapy
- Biology, Psychology
- 2007
The regulation of sleep is classically viewed as the dual interaction of circadian(SCN-based) and homeostatic processes, and the propensity to be asleep or awake at any given time is a consequence of a sleep debt and its interaction with signals from the SCN circadian clock.
[Sleep-wake cycle mechanisms].
- Biology, PsychologyRevista brasileira de psiquiatria
- 2005
An up-to-date understanding of these systems should allow clinicians and researchers to better understand the effects of drugs, lesions, and neurologic disease on sleep and wakefulness.
A neural mechanism of sleep and wakefulness
- Biology, Psychology
- 2003
The present mini-review gives an overview of experimental evidence supporting the old passive reticular hypothesis of sleep, indicating that sleep may result from functional deafferentation from the tonic ascending reticular activity.
Sleep circuitry and the hypnotic mechanism of GABAA drugs.
- Biology, PsychologyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
- 2006
This review discusses data generated in the past 10 years that highlight the role of the hypothalamus in sleep-wake behavior and control, and focuses on the identification of the ventrolateral preoptic nucleus (VLPO) as a sleep center and the hypocretin/orexin cells in the perifornical region of theothalamus as constituting a waking center.
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
- Biology, PsychologyNature Reviews Neuroscience
- 2002
To appreciate the neural underpinnings of sleep, it is important to view this universal mammalian behaviour at multiple levels of its biological organization. Molecularly, the circadian rhythm of…
Current understanding on the neurobiology of sleep and wakefulness
- Psychology, Biology
- 2014
This review briefly summarizes the current awareness on the dynamicity of brain mechanisms of sleep and wakefulness as well as the newer concepts of the biological functions of sleep.
Hypothalamic Murine Models of Sleep-Wake
- 2022
It is confirmed that the general activity profile of the recorded sleep-wake regulatory nuclei is similar to the patterns presented previously in brief recordings of individual nuclei in head-fixed animals.
References
SHOWING 1-10 OF 67 REFERENCES
[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
- BiologyComptes rendus de l'Academie des sciences. Serie III, Sciences de la vie
- 1984
Using a single unit recording technique in freely moving Cats, we have demonstrated the presence of two groups of neurons in the ventrolateral part of the caudal hypothalamus. One is characterized by…
Effects of lateral preoptic area application of orexin‐A on sleep–wakefulness
- Psychology, BiologyNeuroreport
- 2000
The results suggest that the IPOA orexin terminal field or adjacent structures may be a locus of arousal regulation by this peptide and a substrate of sleep-wake regulatory deficits in narcolepsy.
Sleep–waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats
- Biology, PsychologyBrain Research
- 1998
Identification of sleep-promoting neurons in vitro
- BiologyNature
- 2000
It is proposed that the reciprocal inhibitory interaction of such VLPO neurons with the noradrenergic, serotoninergic and cholinergic waking systems to which they project is a key factor for promoting sleep.
Fos Expression in Orexin Neurons Varies with Behavioral State
- Biology, PsychologyThe Journal of Neuroscience
- 2001
Results suggest that activation of orexin neurons may contribute to the promotion or maintenance of wakefulness, and relative inactivity of oxin neuron may allow the expression of sleep.
Dopaminergic Role in Stimulant-Induced Wakefulness
- Biology, PsychologyThe Journal of Neuroscience
- 2001
D dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil.
Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat
- Biology, PsychologyNeuroscience
- 1989
Effect of Lesions of the Ventrolateral Preoptic Nucleus on NREM and REM Sleep
- Biology, PsychologyThe Journal of Neuroscience
- 2000
Two experiments delineate distinct preoptic sites with primary effects on the regulation of NREM sleep, REM sleep, and body temperature in rats, suggesting that they may be a necessary part of the brain circuitry that produces sleep.
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
- Biology, PsychologyCell
- 1999
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 1999
It is shown that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexIn A increases cell firing of intrinsic noradrenergic neurones and modulates neuroendocrine function.