The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.

@article{Guerreiro2015TheSP,
  title={The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.},
  author={Serge Guerreiro and Cl{\'e}lia Florence and Erwann Rousseau and Sabah Hamadat and Etienne C. Hirsch and Patrick P Michel},
  journal={Molecular pharmacology},
  year={2015},
  volume={87 3},
  pages={525-32}
}
To determine whether orexinergic hypothalamic peptides can influence the survival of brainstem dopamine (DA) neurons, we used a model system of rat midbrain cultures in which DA neurons degenerate spontaneously and progressively as they mature. We established that orexin (OX)-B provides partial but significant protection to spontaneously dying DA neurons, whereas the homologous peptide OXA has only marginal effects. Importantly, DA neurons rescued by OXB accumulated DA efficiently by active… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
3 Citations
62 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…