The skin barrier as an innate immune element

@article{Elias2007TheSB,
  title={The skin barrier as an innate immune element},
  author={P. Elias},
  journal={Seminars in Immunopathology},
  year={2007},
  volume={29},
  pages={3-14}
}
  • P. Elias
  • Published 2007
  • Biology, Medicine
  • Seminars in Immunopathology
Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermis mediates a broad set of protective ‘barrier’ functions that includes defense against pathogen challenges. Permeability and antimicrobial function are both co-regulated and… Expand
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References

SHOWING 1-10 OF 96 REFERENCES
Antimicrobial peptides: an essential component of the skin defensive barrier.
  • M. Braff, R. Gallo
  • Biology, Medicine
  • Current topics in microbiology and immunology
  • 2006
  • 141
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.
  • 186
Secretory phospholipase A2 activity is required for permeability barrier homeostasis.
  • 107
Extracellular processing of phospholipids is required for permeability barrier homeostasis.
  • 100
Stratum corneum defensive functions: an integrated view.
  • P. Elias
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 2005
  • 577
The barrier function in atopic dry skin. Disturbance of membrane-coating granule exocytosis and formation of epidermal lipids?
  • 62
Fatty acids are required for epidermal permeability barrier function.
  • 157
  • PDF
Structural and lipid biochemical correlates of the epidermal permeability barrier.
  • 620
Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity.
  • 311
...
1
2
3
4
5
...