The ski oncogene induces muscle differentiation in quail embryo cells.

@article{Colmenares1989TheSO,
  title={The ski oncogene induces muscle differentiation in quail embryo cells.},
  author={Clemencia Colmenares and Edward Stavnezer},
  journal={Cell},
  year={1989},
  volume={59 2},
  pages={293-303}
}
Quail embryo cells (QECs) are primary cultures of fibroblastoid cells that become myogenic after infection with avian retroviruses expressing the ski oncogene (SKVs). ski also stimulates proliferation of QECs and induces morphological transformation and anchorage-independent growth. Paradoxically, ski-transformed clones picked from soft agar are capable of muscle differentiation. ski-induced differentiation is essentially indistinguishable from that of uninfected myoblasts in culture with… CONTINUE READING