The skeleton: Endocrine regulator of phosphate homeostasis

  title={The skeleton: Endocrine regulator of phosphate homeostasis},
  author={M. Doyle and S. M. Jan de Beur},
  journal={Current Osteoporosis Reports},
  • M. Doyle, S. M. Jan de Beur
  • Published 2008
  • Biology, Medicine
  • Current Osteoporosis Reports
  • Phosphorus is an essential element in skeletal development, bone mineralization, membrane composition, nucleotide structure, and cellular signaling. Phosphate, the principal form in which phosphorus is found in the body, is regulated by the complex interplay of the hormones parathyroid hormone (PTH), calcitriol (1,25[OH]2 vitamin D3), and fibroblast growth factor 23 (FGF23). These collectively govern bone mineralization, absorption of phosphorus by the intestine, and renal tubular reabsorption… CONTINUE READING
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