The size of gating charge in wild-type and mutant Shaker potassium channels.

@article{Schoppa1992TheSO,
  title={The size of gating charge in wild-type and mutant Shaker potassium channels.},
  author={Nathan E Schoppa and Kirsty McCormack and Mark A. Tanouye and Fred J. Sigworth},
  journal={Science},
  year={1992},
  volume={255 5052},
  pages={1712-5}
}
The high sensitivity of voltage-gated ion channels to changes in membrane potential implies that the process of channel opening is accompanied by large charge movements. Previous estimates of the total charge displacement, q, have been deduced from the voltage dependence of channel activation and have ranged from 4 to 8 elementary charges (e0). A more direct measurement of q in Drosophila melanogaster Shaker 29-4 potassium channels yields a q value of 12.3 e0. A similar q value is obtained from… CONTINUE READING
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