The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster.

@article{Tolchkov2000TheSA,
  title={The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster.},
  author={Eugenii V Tolchkov and Vanya I. Rasheva and Silvia Bonaccorsi and Thomas Westphal and Vladimir A. Gvozdev},
  journal={Genetics},
  year={2000},
  volume={154 4},
  pages={1611-26}
}
In the In(1LR)pn2a rearrangement, the 1A-2E euchromatic segment is transposed to the vicinity of X heterochromatin (Xh), resulting in position effect variegation (PEV) of the genes in the 2BE region. Practically the whole X-linked heterochromatin is situated adjacent to variegated euchromatic genes. Secondary rearrangements showing weakening or reversion of PEV were obtained by irradiation of the In(1LR)pn2a. These rearrangements demonstrate a positive correlation between the strength of PEV of… CONTINUE READING