The site of action of the anticoccidial salinomycin (Coxistac).

  title={The site of action of the anticoccidial salinomycin (Coxistac).},
  author={L. Chappel},
  journal={The Journal of parasitology},
  volume={65 1},
  • L. Chappel
  • Published 1979
  • Biology, Medicine
  • The Journal of parasitology
The anticoccidial salinomycin has a cidal effect against chicken coccidia. Restricted and unrestricted medication studies and histopathological examinations of chicks infected with Eimeria acervulina, E. maxima, or E. tenella showed that parasites were destroyed within host cells during asexual development. Most sporozoites failed to become trophozoites and were destroyed 30--72 hr after ingestion of oocysts. The drug also affected schizonts during initial nuclear replication by either… Expand
Efficacy of semduramicin and salinomycin against different stages of Eimeria tenella and E. acervulina in the chicken.
The efficacy of a new ionophore, semduramicin, was compared with salinomycin in a series of in ovo and in vivo trials. Semduramicin was more efficacious than salinomycin against Eimeria tenellaExpand
Anticoccidial activity of arprinocid and halofuginone.
It is suggested that halofuginone is active over a broader part of the life cycle than arprinocid, but both drugs had a predominantly coccidiocidal action. Expand
Evaluation of the efficacy of salinomycin in the control of coccidiosis in chicks.
The weight gain of birds given salinomycin at 80 ppm was depressed significantly (P less than .01) at 56 days as a result of decreased feed consumption, and statistical analysis of main effects on weight gain, feed conversion ratio, hematocrit value, and serum optical density showed no significant differences between sal inomycin, monensin, or halofuginone. Expand
Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits.
The anticoccidial effect of narasin against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally infected rabbits. The drug was highly effective inExpand
India is one of the largest and fastest poultry growing industry currently holding the third position in the world in egg production and poultry meat production has reached about 2.2 million tons perExpand
Research Note: Evaluating fecal shedding of oocysts in relation to body weight gain and lesion scores during Eimeria infection
Incorporation of OPG, with BWG and lesion scores, as test parameters to measure coccidiosis intervention strategies, provides a global description of disease that may not otherwise be observed with the 2 latter measurements alone. Expand
Einfluß von Salinomycin auf Scheinbare Verdaulichkeit, Kennzahlen der Pansenfermentation Sowie Mast- und Schlachtergebnisse von Mastrindern
The influence of salinomycin (0, 15, 30 and 60 mg per animal and day) on apparent digestibility of artificially dried grass was investigated in four experiments with five wether each. Three long termExpand
Appraisal of a new patented method for control of chicken coccidiosis
ABSTRACT The aim of this research is to appraise a newly patented method for control of chicken coccidiosis in comparison to a classical approach. The new method implements an invented DisinfectantExpand
Cd(II) and Pb(II) complexes of the polyether ionophorous antibiotic salinomycin
The formation of the salinomycin heavy metal(II) complexes indicates a possible antidote activity of the ligand in case of chronic/acute intoxications likely to occur in the stock farming. Expand
Antitumor activity of the polyether ionophorous antibiotic Monensin and its metal ( II ) complexes
The cytotoxicity of the polyether ionophorous antibiotic Monensin and its complexes [M(Mon)2(H2O)2] (M = Mg, Ca, Co, Mn) was evaluated against permanent human tumor / non-tumor cell lines andExpand