The site of action of epidurally administered opioids and its relevance to postoperative pain management.

@article{George2006TheSO,
  title={The site of action of epidurally administered opioids and its relevance to postoperative pain management.},
  author={Michael J. George},
  journal={Anaesthesia},
  year={2006},
  volume={61 7},
  pages={659-64}
}
The use of epidurally administered opioids to control postoperative pain is a well established and widely accepted technique. However, despite this longstanding use, there is still an ongoing debate concerning the site of action of the opioids used. Some argue that analgesia is mediated by a spinal mechanism and others that a supraspinal mechanism is responsible. On close inspection of the evidence it becomes apparent that epidural opioids act predominantly spinally when administered as a bolus… CONTINUE READING