The site and the mode of analgesic actions exerted by clonidine in monkeys.

@article{Wang1985TheSA,
  title={The site and the mode of analgesic actions exerted by clonidine in monkeys.},
  author={Y. C. Wang and Chain Fa Su and M. T. Lin},
  journal={Experimental neurology},
  year={1985},
  volume={90 3},
  pages={479-88}
}
We used intracerebral administration of clonidine in monkeys to map effective sites for analgesia. The jaw opening reflex elicited by tooth pulp stimulation was used for analgesia testing. We found that the most consistently effective sites for analgesia in monkeys are in at least three brain regions: the diencephalic periventricular gray, the dorsal raphe nuclei, and the periaqueductal gray. In addition, the analgesia induced by intracerebral administration of clonidine was effectively… CONTINUE READING