The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.

@article{Lugrin2013TheSI,
  title={The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.},
  author={J{\'e}r{\^o}me Lugrin and Eleonora Ciarlo and Alba Santos and Ga{\"e}l Grandmaison and Isis dos Santos and Didier le Roy and Thierry Roger},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1833 6},
  pages={1498-510}
}
Sirtuins (SIRT1-7) are NAD(+)-dependent histone deacetylases (HDACs) that play an important role in the control of metabolism and proliferation and the development of age-associated diseases like oncologic, cardiovascular and neurodegenerative diseases. Cambinol was originally described as a compound inhibiting the activity of SIRT1 and SIRT2, with efficient anti-tumor activity in vivo. Here, we studied the effects of cambinol on microbial sensing by mouse and human immune cells and on host… CONTINUE READING

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Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
Going well along with its powerful anti - inflammatory activity , cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock .
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