The sinister face of heme oxygenase-1 in brain aging and disease

@article{Schipper2019TheSF,
  title={The sinister face of heme oxygenase-1 in brain aging and disease},
  author={Hyman M. Schipper and Wei Song and Ayda Tavitian and Marisa Cressatti},
  journal={Progress in Neurobiology},
  year={2019},
  volume={172},
  pages={40-70}
}
Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant and inflammatory stimuli act on diverse consensus sequences within the Hmox1 promoter to rapidly induce the gene. There is ample evidence attesting to the beneficial effects of HO-1 upregulation in brain. By converting pro-oxidant heme to the antioxidants, biliverdin and bilirubin, HO-1/biliverdin reductase may help… Expand
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