The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin.

@article{Dean1992TheSV,
  title={The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin.},
  author={Frank B. Dean and James A. Borowiec and Toshihiko Eki and Jerard Hurwitz},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 20},
  pages={14129-37}
}
An initial step in the replication of simian virus (SV40) DNA is the ATP-dependent formation of a double hexamer of the SV40 large tumor (T) antigen at the SV40 DNA replication origin. In the absence of DNA, T antigen assembled into hexamers in the presence of magnesium and ATP. Hexameric T antigen was stable and could be isolated by glycerol gradient centrifugation. The ATPase activities of hexameric and monomeric T antigen isolated from parallel glycerol gradients were identical. However… CONTINUE READING

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In DNA Tumor Viruses

A. R. Buchman, L. Burnett, P. Berg
1980
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