The silent treatment: siRNAs as small molecule drugs

@article{Dykxhoorn2006TheST,
  title={The silent treatment: siRNAs as small molecule drugs},
  author={Derek Michael Dykxhoorn and Deborah Palliser and Judy Lieberman},
  journal={Gene Therapy},
  year={2006},
  volume={13},
  pages={541-552}
}
As soon as RNA interference (RNAi) was found to work in mammalian cells, research quickly focused on harnessing this powerful endogenous and specific mechanism of gene silencing for human therapy. RNAi uses small RNAs, less than 30 nucleotides in length, to suppress expression of genes with complementary sequences. Two strategies can introduce small RNAs into the cytoplasm of cells, where they are active – a drug approach where double-stranded RNAs are administered in complexes designed for… CONTINUE READING

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As soon as RNA interference ( RNAi ) was found to work in mammalian cells , research quickly focused on harnessing this powerful endogenous and specific mechanism of gene silencing for human therapy .
As soon as RNA interference ( RNAi ) was found to work in mammalian cells , research quickly focused on harnessing this powerful endogenous and specific mechanism of gene silencing for human therapy .
As soon as RNA interference ( RNAi ) was found to work in mammalian cells , research quickly focused on harnessing this powerful endogenous and specific mechanism of gene silencing for human therapy .
As soon as RNA interference ( RNAi ) was found to work in mammalian cells , research quickly focused on harnessing this powerful endogenous and specific mechanism of gene silencing for human therapy .
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