The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery.

@article{Lyons2008TheSO,
  title={The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery.},
  author={John G Lyons and Paul Blackie and Clement L. Higginbotham},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={351 1-2},
  pages={201-8}
}
The body of work described in this research paper outlines the use of PEO/PCL blends in the production of monolithic matrices for oral drug delivery. Several batches of matrix material were prepared with carvedilol used as the active pharmaceutical ingredient. The matrices were prepared using various extrusion parameters to investigate the effect of screw speed and barrel temperature on the properties of the drug delivery devices. The resultant extrudate was characterised using steady state… CONTINUE READING